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Showing 1–50 of 1820 results
  • Branched ionizable lipids have aroused great interest for mRNA delivery. Here, the authors devise an in situ construction method for combinatorial synthesis of degradable branched ionizable lipids and summarize key design criteria to enable potent delivery of mRNA therapeutics and gene editors.

    • Xuexiang Han
    • Junchao Xu
    • Michael J. Mitchell
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13
  • Tumour cell behaviour is an underdeveloped target for cancer intervention. Here the authors report on a spatiotemporal interaction between tumour cells and osteoclasts in initial bone metastases and propose a behaviour-targeting therapy with an in situ physical killing strategy.

    • Chenhui Gu
    • Pengfei Chen
    • Xianfeng Lin
    Research
    Nature Nanotechnology
    P: 1-11
  • The spacing of ligands presented to cells can have a huge impact on cellular responses. DNA origami is used to block structures to control the distribution of Toll-like receptor ligands and optimize presentation in the activation of dendritic cells in cancer immunotherapy.

    • Yang C. Zeng
    • Olivia J. Young
    • William M. Shih
    Research
    Nature Nanotechnology
    P: 1-11
  • Insects have been shown to have the ability to detect different chemical agents. Here, the authors present a nanomaterial-assisted neuromodulation strategy to augment the chemosensory abilities of insects via photothermal effect and on-demand neurotransmitter release from cargo-loaded nanovehicles to augment natural sensory function.

    • Prashant Gupta
    • Rishabh Chandak
    • Srikanth Singamaneni
    Research
    Nature Nanotechnology
    P: 1-11
  • The treatment of hypertrophic scar (HS) is hindered by the low bioavailability of drugs and the pathological microenvironment. Here the authors report a separating microneedle drug delivery system responsive to high reactive oxygen species levels and overexpression of matrix metalloproteinases to remodel the pathological microenvironment for HS treatment.

    • Zhuo-Ran Yang
    • Huinan Suo
    • Jintao Zhu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17
  • Cholesterol (Chol) transfer from lipid bilayer jeopardizes membrane stability and causes premature payload leakage, yielding suboptimal efficacy. Here, the authors report a Chol-modified sphingomyelin (SM) bilayer via covalently conjugating Chol to SM, which retains Chol condensing ability and improves pharmacokinetics and therapeutic delivery of various drugs in diverse disease animal models.

    • Zhiren Wang
    • Wenpan Li
    • Jianqin Lu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15
  • The intravenous injection of neutrophils bearing discoidal polymer microscale ‘patches’ on their surfaces reduces tumour burden in mice owing to the patch-induced polarization of the neutrophils towards an antitumour phenotype.

    • Ninad Kumbhojkar
    • Supriya Prakash
    • Samir Mitragotri
    Research
    Nature Biomedical Engineering
    P: 1-14
  • Identifying pulmonary delivery of lipid libraries poses an obstacle for mRNA drugs. Here, the authors use a barcoded screening system to identify lung-targeting of cationic, degradable lipid-like materials for mRNA delivery and gene editing in female preclinical models.

    • Lulu Xue
    • Alex G. Hamilton
    • Michael J. Mitchell
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15
  • The delivery of CRISPR RNPs has potential advantages over other genome editing approaches, including reduced off-target editing and reduced immunogenicity. Here the authors report self-deliverable Cas9 RNPs capable of robustly editing cultured cells in vitro and the mouse brain upon direct injections.

    • Kai Chen
    • Elizabeth C. Stahl
    • Jennifer A. Doudna
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11
  • Achieving targeted drug delivery for calcified aortic valve is challenging. Here, the authors find that protease activated receptor 2 (PAR2) is up-regulated on calcified valves and develop a magnetic nanocarrier functionalized with PAR2-targeting peptide for dual-active drug delivery.

    • Jinyong Chen
    • Tanchen Ren
    • Xianbao Liu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20
  • Manufacturing complexities, low yield and stability issues have hampered the clinical translation and scaling-up of immunoliposomes to meet the needs of pharmaceutical-grade products. The authors propose a one-step method of incorporating chimeric nanobodies tagged to hydrophobic linkers into liposomes, allowing targeted delivery of small-molecule anti-cancer drugs to tumours.

    • Md. Mofizur Rahman
    • Jing Wang
    • Yuan Wan
    Research
    Nature Nanotechnology
    P: 1-7
  • In regenerative medicine, stem-cell-derived extracellular vesicles are emerging as cell-free nanotherapeutics. Here, the authors show that coating these nanovesicles with blood proteins such as albumin improves their uptake by liver cells, offering a better treatment strategy for liver diseases.

    • Revadee Liam-Or
    • Farid N. Faruqu
    • Khuloud T. Al-Jamal
    ResearchOpen Access
    Nature Nanotechnology
    P: 1-10
  • Insulin injections are not ideal and have an increased risk of hypoglycaemia. A preferable oral formulation based on silver sulfide quantum dots coated with a chitosan/glucose polymer is discussed, which has controlled insulin release and reduced risk of hypoglycaemia, and demonstrates applications in rodent and non-human primate models.

    • Nicholas J. Hunt
    • Glen P. Lockwood
    • Victoria C. Cogger
    ResearchOpen Access
    Nature Nanotechnology
    P: 1-11
  • Triggering the PD-1/PD-L1 immune checkpoint is an attractive therapeutic approach in inflammatory bowel disease, and PD-L1, conjugated to the Fc part of an immunoglobulin (PD-L1-Fc) has been shown to be effective in mouse models. Here authors show that fusing to reactive oxygen species (ROS)-responsive nanoparticles improves effect of PD-L1-Fc due to targeting to inflammation sites, while systemic toxicity is reduced.

    • Xudong Tang
    • Yangyang Shang
    • Lei Chen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18
  • Limited tumor cell delivery is a major challenge for the efficacious delivery of siRNAs to silence traditionally undruggable oncogenes. Here the authors optimize siRNAs for in situ binding to albumin through C18 lipid modifications and show the application of the lead conjugate structure for targeting MCL1 in orthotopic breast tumors in mice.

    • Ella N. Hoogenboezem
    • Shrusti S. Patel
    • Craig L. Duvall
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20
  • Immune checkpoint blockade-based immunotherapy has shown limited efficacy in patients with glioblastoma (GBM). Here the authors describe the design of redox-responsive micelles for increasing the delivery of paclitaxel and anti-PD-L1 in the brain, showing improved anti-tumor immune response in preclinical GBM models.

    • Zhiqi Zhang
    • Xiaoxuan Xu
    • Shenghong Ju
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20
  • The dynamic protein corona hinders the uptake of nanocarriers in desired target cell populations, limiting their bench-to-bedside translation. Here the authors reveal that the modification of hydroxyl and amino functional groups on nanovesicles can rationally regulate the composition of protein coronas to improve the efficiency of targeted drug delivery.

    • Yunqiu Miao
    • Lijun Li
    • Yong Gan
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20
  • Treatment of the chronic disease ulcerative colitis is impeded by systemic side effects of orally administered drugs. Here the authors develop a gel that uses the rectal temperature as a mechanism to trigger solidification for localized delivery of colitis therapeutics.

    • Marianna Carone
    • Marianne R. Spalinger
    • Simone Aleandri
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14
  • Long-term control of therapeutic transgene expression is needed. Here the authors report a muscone-induced transgene system packaged into AAVs based on a G protein-coupled murine olfactory receptor and a synthetic cAMP-responsive promoter: they show dose- and exposure-time-dependent gene expression control in mice.

    • Xin Wu
    • Yuanhuan Yu
    • Haifeng Ye
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16
  • In this work, the authors report the use of a computationally and rationally designed self-assembling peptide that has robust antiviral capability with demonstrated specificity in binding to SARS-CoV-2 and inhibition of viral entry into human cells.

    • Joseph Dodd-o
    • Abhishek Roy
    • Vivek Kumar
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14
  • Different approaches have been described for the transdermal delivery of drugs. Here the authors report the design of a fluorocarbon modified chitosan-based non-invasive transdermal platform for the delivery of biomacromolecules, such as viral antigens for vaccines or immune checkpoint inhibitors for melanoma immunotherapy.

    • Wenjun Zhu
    • Ting Wei
    • Zhuang Liu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15
  • The mechanical dysregulation of cells is associated with several diseases and strategies to deliver drugs based on the “mechanical phenotype” of a cell are desirable. Here, the authors design and characterize DNA mechanocapsules comprised of DNA tetrahedrons that are force responsive, and showed they can encapsulate macromolecular cargo and release it upon application of force.

    • Arventh Velusamy
    • Radhika Sharma
    • Khalid Salaita
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13
  • Proteins absorbed on nanomaterials often lose function due to denaturation. A poly(propylene sulfone) nanoparticle with site-specific dipole relaxation has been reported, which allows proteins to anchor to the nanoparticle without disrupting the hydrogen bonding or structure maintaining the protein functionality.

    • Fanfan Du
    • Clayton H. Rische
    • Evan A. Scott
    Research
    Nature Nanotechnology
    P: 1-7
  • Cytokine interleukin-12 (IL-12) has potential for tumour suppression yet off-target effects limit potential applications. Here the authors report on the delivery of IL-12 mRNA encapsulated in extracellular vesicles to lungs via inhalation and demonstrate the immunotherapeutic potential of targeted cytokine mRNA therapy.

    • Mengrui Liu
    • Shiqi Hu
    • Ke Cheng
    Research
    Nature Nanotechnology
    P: 1-11
  • Protein degradation is a powerful tool for a range of applications and therapies. Here, a selective autophagy receptor mimetic against mutant p53 protein is developed to substantially elevate autophagy levels and to recognize and transport mutant proteins for autophagy-mediated degradation and anticancer effect.

    • Xiaowan Huang
    • Ziyang Cao
    • Yunjiao Zhang
    Research
    Nature Nanotechnology
    P: 1-9
  • Microneedle patches that can actively address individual needles are challenging to realize. Here, the authors introduce a spatiotemporal on-demand patch for precise and personalized drug delivery, utilizing electrically triggered control with drug-loaded microneedles and biocompatible metallic membranes.

    • Yihang Wang
    • Zeka Chen
    • Wubin Bai
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18
  • The poor tumour delivery efficacy of GPX4 inhibitor has dampened its in vivo therapeutic value. Here the authors report a peptide ferriporphyrin conjugate to improve tumour penetration, endocytosis and GPX4 inhibition, synergistically enhancing its anticancer activity by ferroptosis.

    • Da-Yong Hou
    • Dong-Bing Cheng
    • Hao Wang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16
  • Protecting the whole small intestine from radiation-induced intestinal injury during the radiotherapy of abdominal or pelvic solid tumors remains an unmet clinical need. Here the authors use a natural microalga to readily construct an oral delivery system to achieve effective radioprotection for the small intestine.

    • Dongxiao Zhang
    • Danni Zhong
    • Min Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18
  • Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing timing in distinct healing stages. Here, the authors report a core-shell structured microneedle array patch with programmed functions which dynamically modulates the wound immune microenvironment according to the varied healing phases

    • Ying Zhang
    • Shenqiang Wang
    • Zhen Gu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13
  • Local anesthetic sustained release systems suffer from untriggered rapid drug release upon application. Here the authors overcome this issue by covalently linking tetracaine to a polymer gel via a photo-cleavable linkage, enabling light-triggered and repeatable drug release.

    • Wei Zhang
    • Tianjiao Ji
    • Daniel S. Kohane
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8
  • A pro-tumorigenic role of iRhom1 has been described in several cancer types. Here the authors show that iRhom1 regulates sensitivity to chemotherapy and immune response, as well they report that CD44 targeting nanoparticle-mediated co-delivery of iRhom1 pre-siRNA promotes anti-tumor immune responses in preclinical cancer models.

    • Zhangyi Luo
    • Yixian Huang
    • Song Li
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20
  • Functionalization of C-H bonds typically requires harsh reagents or metal catalysts. Here the authors report a metal-free C-H sulfenylation/rearrangement to form C-S and S=N bonds under simple, biocompatible conditions, and apply this to the synthesis of fluorogenic phospholipid vesicles.

    • Feng Xiong
    • Liang Lu
    • Jing Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-7
  • Autologous skin flap transplantation is a common method to repair complex soft tissue defects. Here the authors develop a hydrogel patch that releases carbon monoxide and nitric oxide gases on demand, to afford a timely blood supply for skin flap transplantation during surgery, just improving the incidence of distal necrosis of the flap and reducing long-term functional loss.

    • Xiaoduo Tang
    • Jingyan Ren
    • Bai Yang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14
  • Polyorganophosphazenes are macromolecules that selfassemble with antigenic proteins to enable biological functionality. Here, direct imaging by cryogenic electron microscopy reveals the coil structure of their individual chains and compact stiffened coils of their complexes with proteins.

    • Raman Hlushko
    • Edwin Pozharski
    • Alexander K. Andrianov
    ResearchOpen Access
    Communications Materials
    Volume: 5, P: 1-9
  • Poor renal distribution of antibody-based drugs limits the treatment efficiency for diabetic nephropathy and causes side effects. Here, the authors prepare an antibody fragment drug conjugate, antiVEGFR2 F(ab′)2-SS31, improving renal distribution and meriting drug validation in diabetic nephropathy therapy.

    • Di Liu
    • Yanling Song
    • Yongzhong Du
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14
  • Small interfering RNA is degraded by plasma and can’t cross the cell membrane due to its negative charge. Here, the authors present an influenza inspired polymer carrier, capable of local RNA delivery, which degrades to a non-toxic by-product, and is thus suitable for multiple doses.

    • Nghia P Truong
    • Wenyi Gu
    • Michael J Monteiro
    Research
    Nature Communications
    Volume: 4, P: 1-7
  • Intratumoral abundance of chemokines, such as CXCL9, is an important driver of T cell infiltration in tumors. Here the authors describe the design of a tumor-specific expression strategy to drive secretion of CXCL9 and an anti-PD-L1 scFv (αPD-L1) in the tumor microenvironment, promoting T cell recruitment and anti-tumor immune response in preclinical cancer models.

    • Yue Wang
    • Shi-Kun Zhou
    • Jun Wang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18
  • Cyclic peptides show promise for modulating difficult disease targets; however, they often cannot be administered orally. The authors developed a method to synthesize and screen large libraries of small cyclic peptides while enabling the simultaneous interrogation of activity and permeability. This approach was applied to the disease target thrombin to discover peptides with high affinity, stability and oral bioavailability of up to 18% in rats.

    • Manuel L. Merz
    • Sevan Habeshian
    • Christian Heinis
    ResearchOpen Access
    Nature Chemical Biology
    P: 1-10
  • Prodrug photolysis enables spatiotemporal control of drug release at the desired lesions, but most of the photocleavable groups cannot be directly activated by near-infrared (NIR) light that features deep penetration and low phototoxicity. Here, the authors report an upconversion-like process via only one step of energy transfer for NIR light-triggered prodrug photolysis.

    • Kaiqi Long
    • Wen Lv
    • Weiping Wang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13
  • The treatment of Parkinson’s disease (PD) is hampered by the lack of effective blood–brain barrier (BBB) traversing drugs. Here, the authors report nanozyme-integrated metal-organic frameworks with antioxidant activity and chiral-dependent BBB transendocytosis as anti-neuroinflammatory agents for PD treatment.

    • Wei Jiang
    • Qing Li
    • Kelong Fan
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18
  • Treating acute disease like anaphylaxis is challenging due to the inability to administer therapeutics in a timely manner and regulate pharmacokinetics precisely within a short time window. Here the authors develop active acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand acute disease management.

    • Junhua Xu
    • Hongwei Cai
    • Feng Guo
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-9
  • Various anti-fibrotic drugs have been applied to urethral stricture by irrigation or submucosal injection, but their clinical feasibility and effectiveness are limited. Here, the authors design a protein-based nanofilm-controlled drug delivery system with anti-biofilm properties that can be assembled on a catheter.

    • Juanhua Tian
    • Delai Fu
    • Peng Yang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17