The Washington PostDemocracy Dies in Darkness

Pfizer had clues its blockbuster drug could prevent Alzheimer’s. Why didn’t it tell the world?

June 4, 2019 at 7:05 p.m. EDT
Pfizer’s arthritis drug appeared to reduce the risk of getting Alzheimer’s disease. The Washington Post’s Chris Rowland explains why Pfizer did not pursue it. (Video: REF:Luis Velarde/The Washington Post)

A team of researchers inside Pfizer made a startling find in 2015: The company’s blockbuster rheumatoid arthritis therapy Enbrel, a powerful anti-inflammatory drug, appeared to reduce the risk of Alzheimer’s disease by 64 percent.

The results were from an analysis of hundreds of thousands of insurance claims. Verifying that the drug would actually have that effect in people would require a costly clinical trial — and after several years of internal discussion, Pfizer opted against further investigation and chose not to make the data public, the company confirmed.